Mitochondrial Hormesis and Diabetic Complications
نویسندگان
چکیده
منابع مشابه
Mitochondrial Hormesis and Diabetic Complications
The concept that excess superoxide production from mitochondria is the driving, initial cellular response underlying diabetes complications has been held for the past decade. However, results of antioxidant-based trials have been largely negative. In the present review, the data supporting mitochondrial superoxide as a driving force for diabetic kidney, nerve, heart, and retinal complications a...
متن کاملComment on Sharma. Mitochondrial Hormesis and Diabetic Complications. Diabetes 2015;64:663-672.
We have read with interest the recently published Perspective by Kumar Sharma (1) and write to express our views. The author presents a controversial viewpoint, which clearly challenges the mitochondrial superoxide theory proposed by Michael Brownlee in 2001 (2). Thus, it is proposed that there may be reduced, rather than increased, mitochondrial superoxide production due to compromised electro...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2015
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db14-0874